Protein name:
Krueppel-like factor 1 ;
Alternative:
Erythroid krueppel-like transcription factor (EKLF) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with CBP and EP300; the interactions enhance the transactivation activity. Interacts with PCAF; the interaction does not acetylate EKLF and inhibits its transactivation activity.
Function:
Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.
Subcellular Location:
Nucleus
Colocalizes with SUMO1 in nuclear speckles.
Protein Attributes:
50:
MATAETALPS | ISTLTALGPF | PDTQDDFLKW | WRSEEAQDMG | PGPPDPTEPP |
100:
LHVKSEDQPG | EEEDDERGAD | ATWDLDLLLT | NFSGPEPGGA | PQTCALAPSE |
150:
ASGAQYPPPP | ETLGAYAGGP | GLVAGLLGSE | DHSGWVRPAL | RARAPDAFVG |
200:
PALAPAPAPE | PKALALQPVY | PGPGAGSSGG | YFPRTGLSVP | AASGAPYGLL |
250:
SGYPAMYPAP | QYQGHFQLFR | GLQGPAPGPA | TSPSFLSCLG | PGTVGTGLGG |
300:
TAEDPGVIAE | TAPSKRGRRS | WARKRQAAHT | CAHPGCGKSY | TKSSHLKAHL |
350:
RTHTGEKPYA | CTWEGCGWRF | ARSDELTRHY | RKHTGQRPFR | CQLCPRAFSR |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Krueppel-like factor 1
ELISA Kit for Human Krueppel-like factor 1
CLIA Kit for Human Krueppel-like factor 1
CLIA Kit for Human Krueppel-like factor 1
Polyclonal Antibody for Human Krueppel-like factor 1
Polyclonal Antibody for Human Krueppel-like factor 1
Monoclonal Antibody for Human Krueppel-like factor 1
Monoclonal Antibody for Human Krueppel-like factor 1
Protein for Human Krueppel-like factor 1
Protein for Human Krueppel-like factor 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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